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Health Report
Estrogen
Unknown Author
(The Gender Centre advise that this article may not be current and as such certain content, including
but not limited to persons, contact details and dates may not apply. Where legal authority or medical related matters are
cited, responsibility lies with the reader to obtain the most current relevant legal authority and/or medical
publication.)
Estrogen
Estrogen (Greek Oistros, mad desire, + gennan, to produce). Any natural or artificial substance that induces estrogenic activity; more
specifically the estrogenic hormones, estradiol and estrone, produced by the ovary. Estrogens are responsible for the development of
secondary sexual characteristics. Natural estrogens include estradiol, estrone, and their metabolic product, estriol. When used
therapeutically, estrogens are usually given in the form of a conjugate such as ethinyl estradiol, conjugated estrogens, or the synthetic
estrogenic substance, diethylstibestrol.
It is considered important to closely observe people treated with estrogens for any malignant changes in the breast. Estrogen should be
administered in the lowest effective dose.
Feminization
If feminization is to occur in a genetic male, There must be an increase in estrogens as well as a decrease in testosterone. Think of it
as a see-saw. It for this reason that most hormone therapies for the feminization of genetic men include both estrogens as well as some
type of anti-androgenic drugs such as spironolactone, aldactone, proscar etc.
The rate of feminization varies from person to person depending on any number of personal factors such as the dosage used (although
higher dosage appears to speed up feminization it does carry with it an increased risk. This along with the fact that there is no
difference between feminization achieved over a greater amount of time with fewer drugs and thus less detriment to health and that achieved
through higher dosage over a shorter period of time. It is considered far more prudent to maintain health and achieve the goal of
feminization over a greater amount of time than to speed ahead disregarding the very serious health risks created by this approach.)
Genetic constitution (some people are able to absorb estrogens better than other, as well as some have less over all testosterone to
overcome.), as well as psycho-emotional conditions and over all health.
Generally speaking, feminization will begin to be noticed about 1-3 months after starting on an adequate regime. Libido will decrease as
well as ejaculate will become less in quantity (due to the shrinking of the prostate gland).
Eventual impotency and sterility is generally considered reversible for the first few months. The skin will start to become softer as
well as drier. And about this time ones breasts may start to "bud" (enlargement starting around the areolas and slowly continuing
to fill the breast area with breast tissue. This will cause the breasts to become very sensitive to being bumped or touched), as well as
some fat redistribution to the breast area, face (causing an increased roundness and decidedly more female looking lines), hips, and
thighs. Body hair will begin to get finer, lighter and sparser while hair on the head gets somewhat fuller. Muscle mass decreases along
with significant amounts of physical strength.
Many people report increased emotionality, decreased spatial skills, changes in sexual orientation and an over all passivity. It may
well effect brain functions. Changing ones interests, thinking process's etc. It is difficult to know if these effects are a result of new
openings and closings in what is socially acceptable or is due to the overall hormonal balance. It is the opinion of the author as a result
of personal experience, that hormonal therapy does effect virtually all aspects of ones life experience.
Estrogen replacement therapy does not raise the pitch of ones voice, decrease structural body size or make your feet smaller. Sorry
girls.
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Inc. which is funded by the Department of Community Services under the
S.A.A.P. Program and supported by the
N.S.W. Health Department through the
AIDS and Infectious Diseases Branch. Polare provides a
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Any submission which appears in Polare may be published on our internet site. Opinions expressed in this publication do not
necessarily reflect those of the Editor, The Gender Centre Inc.I, the
Department of Community Services or the N.S.W. Department of Health.
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